1. In every circumstance, always pray to God and say, "Thy will be done."
Padre Pio wrote to Annita Rodote (a spiritual daughter), "learn to recognize and adore God's will in everything. Frequently repeat the divine words of our dear Master, "Thy will be done on earth as it is in Heaven." Repeat it in temptation and in the trails to which Jesus will be pleased to subject you. Repeat it still when you find yourself immersed in the ocean of Jesus' love. This will be your anchor and your salvation."
2. Offer every action up to God.
Padre Pio urged his disciples to make short mental prayers offering everything they did, no matter how simple or trivial, to Christ. "Let's refer everything to God and live and move in Him," he wrote to Maria Gargani. Along with everything else, the Christian was to offer his sufferings to God as a sacrifice. While Padre Pio did not urge everyone to offer himself as a victim, he did teach that we should offer suffering, when it comes, to God to be used for his good purposes. To the same Donna Maria, he wrote, "Physical and spiritual ills are the most worthy offering you can make to Him Who saved you by suffering."
3. Never Worry.
Anxieties, Pio taught, are a waste of time. Through the machinations of the devil, who makes use of them, anxieties befoul our good actions because of our lack of confidence in God's goodness.
4. Aspire to the Heavenly prize.
"How lovable an eternity in heaven is, and how miserable the affairs of the world are! Padre Pio exclaimed to Donna Erminia. "Continually aspire to the former and fervently despise the comforts and the affairs of this mortality."
Source: Padre Pio: The True Story: by C. Bernard Ruffin